Cold agglutinins are IgM autoantibodies which agglutinate erythrocytes at temperatures between 0 and 32 degrees Celsius. They are normally made by the immune system in response to infection. Healthy people generally have low levels of cold agglutinins in their blood. Individuals with cold agglutinin disease present with signs and symptoms of hemolytic anemia. When a person is exposed to cold temperatures, these symptoms can include numbness, burning, pain, or pale skin of the fingertips, toes, ears, or nose. HIGH titres of cold agglutinins may be caused by infections such as mycoplasma pneumonia, infectious mononucleosis, malaria, cytomegalovirus, hepatitis C, cirrhosis, or autoimmune disease.
Serum + EDTA whole blood. Allow to clot at 37°C then separate serum. Kept warm during transportation.
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