Anti–glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. The target antigen is the alpha-3 chain of type IV collagen. The resultant clinical syndrome encompasses a spectrum ranging from mild or no renal involvement to rapidly progressive glomerulonephritis. The combination of glomerulonephritis and pulmonary hemorrhage is commonly referred to as Goodpasture syndrome.
Separate serum from cells ASAP or within 2 hours of collection.
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