Anti-HBc IgM antibodies, directed against viral core components, specifically mark acute hepatitis B. They may be the only indication of recent infection when the HBs antigen has already disappeared. See Hepatitis Bs Antigen (HBsAg), Serum; and Hepatitis B Virus (HBV) DNA Quantitative, PCR
Specimen Preparation Separate serum from cells ASAP or within 2 hours of collection.
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