The HOMA-IR score is used to estimate the degree of insulin resistance in non-diabetic or early stage diabetic patients. It can be applied if intact proinsulin levels are in the normal range, as the total secretion activity of the ?-cell is under this condition represented by the fasting insulin levels. Insulin resistance is assumed if the score value exceeds 2. Of particular interest are changes in the HOMA score during therapeutic interventions, as a score reduction represents an improvement in insulin sensitivity.
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