Circulating lupus anticoagulants (also called lupus antibodies) are defined by their in vitro inhibitory activity on phospholipid-dependent coagulation reactions. The presence of anti-phospholipid antibodies (LA or anti-cardiolipin antibodies) is associated with recurrent venous or arterial thrombosis and/or recurrent abortions. This condition may be primary or secondary to a range of etiologies including autoimmune disease (e.g. SLE), neoplasia and certain types of infection. LA are often detected in children who have recently undergone tonsilectomy or adenoidectomy but this is usually an insignificant result not indicating any predisposition to thrombosis or hemorrhage; in most such cases, the LA disappear within six months. Related tests: Phospholipid Antibodies, Cardiolipin Antibodies, B-2-Glycoprotein I Antibodies, and ANA.
Minimum 2 ml plasma required. Freeze immediately.
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