Anti-reticulin antibodies are directed against the connective tissue component of reticulin and are associated with celiac disease. It is considered as the third useful marker for following celiac disease, the first two being anti-gliadin and anti-endomysial antibodies. Anti-reticulin antibodies are not as specific or sensitive as the other autoantibodies. It is found in about 60% of celiac disease patients and about 25% of patients with dermatitis herpetiformis. Only the IgA subclass is relevant (since IgA is made in the intestine) and is measured almost exclusively. IgG versions may be ordered either to complement the IgA testing or ordered due to increased incidence of selective IgA deficiency in patients with celiac disease. See Gliadin Antibodies, and Endomysial Antibodies.
Total IgA measurement is recommended to rule out false negative results due to IgA deficiency.
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