Selenium (Se) is a part of the enzyme glutathione peroxidase, which metabolizes hydroperoxides formed from polyunsaturated fatty acids. Selenium is also a part of the enzymes that deiodinate thyroid hormones. Generally, selenium acts as an antioxidant that works with vitamin E. Workers in the glass, dye and electronics industries, and those who use fungicides may be at risk of overexposure. DEFICIENCY predisposes patients to Keshan disease, an endemic viral cardiomyopathy affecting primarily children and young women. HIGH doses of selenium cause toxicity. Manifestations include hair loss, abnormal nails, dermatitis, peripheral neuropathy, nausea, diarrhea, fatigue, irritability, and a garlic odor of the breath.
Hemolyzed and lipemic samples are not acceptable.
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