Neuron-Specific Enolase (NSE) is the most abundant form of the glycolytic enzyme enolase found in adult neurons and is thought to serve as a growth factor in neurons. NSE is useful in studying neuronal differentiation and is, therefore, a valuable tool for visualizing the entire nervous and neuroendocrine systems. Serum levels of NSE have been associated with such disease states as Alzheimer’s, Huntington’s Chorea, neuroblastoma, head trauma, neuroendocrine malignancies, and small cell carcinomas of the lung. Measurement of NSE levels in patients with these diseases can provide information about the extent of the disease and the patients prognosis (outlook), as well as about the patients response to treatment.
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